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Longer titles found: Bromodomain-containing protein 3 (view), Bromodomain and WD repeat-containing protein 1 (view), Bromodomain and WD repeat-containing protein 3 (view)

searching for Bromodomain 73 found (130 total)

alternate case: bromodomain

BRD2 (1,177 words) [view diff] exact match in snippet view article find links to article

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET)

BRD7 (1,072 words) [view diff] exact match in snippet view article find links to article

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene. BRD7 has been shown to interact with IRF2 and HNRPUL1. BRD7

BPTF (1,104 words) [view diff] exact match in snippet view article find links to article

much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation

BRD8 (1,128 words) [view diff] exact match in snippet view article find links to article

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene. The protein encoded by this gene interacts with thyroid hormone

BAZ2A (426 words) [view diff] exact match in snippet view article find links to article

Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene. GRCh38: Ensembl release 89: ENSG00000076108

WD repeat-containing protein 11 (466 words) [view diff] exact match in snippet view article find links to article

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by

KAT2A (1,168 words) [view diff] exact match in snippet view article find links to article

(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein

ZMYND8 (785 words) [view diff] exact match in snippet view article find links to article

T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator

LeDock (767 words) [view diff] exact match in snippet view article find links to article

Spiliotopoulos, Dimitrios; Caflisch, Amedeo (2014-06-01). "Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking". Bioorganic & Medicinal

Gunda Georg (829 words) [view diff] exact match in snippet view article find links to article

; Ward, T. R.; Schönbrunn, E.; Georg, G. I.; Pomerantz, W. C. K. BET Bromodomain Inhibitors with One-step Synthesis Discovered from a Virtual Screen.

RFC1 (2,249 words) [view diff] exact match in snippet view article find links to article

Cheong J, Bermudez VP, Tamura T, et al. (September 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

WAC protein domain (415 words) [view diff] exact match in snippet view article find links to article

organisms. It is found in association with other domains such as the bromodomain, the PHD-type zinc finger, DDT or WAKS. The DNA-binding region of Acf1

Alveolar rhabdomyosarcoma (1,303 words) [view diff] exact match in snippet view article find links to article

2017). "PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability". Cancer Discovery. 7 (8): 884–899. doi:10.1158/2159-8290

Triple-negative breast cancer (3,573 words) [view diff] exact match in snippet view article find links to article

(LAS17) shows encouraging results in a pre-clinical study. Recently, BET (Bromodomain and Extra-Terminal Domain Proteins) inhibitors have shown anti-tumor

Nuclear protein in testis gene (2,606 words) [view diff] exact match in snippet view article find links to article

immature-appearing cells containing a BRD4-NUTM1 fusion gene. BRD4 is the bromodomain-containing protein 4 gene. A fusion gene is an abnormal gene consisting

RFC2 (1,570 words) [view diff] exact match in snippet view article find links to article

Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

E2F2 (1,241 words) [view diff] exact match in snippet view article find links to article

association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353

RFC4 (1,792 words) [view diff] exact match in snippet view article find links to article

Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

Birabresib (302 words) [view diff] exact match in snippet view article find links to article

Switzerland AG. Braun T, Gardin C (July 2017). "Investigational BET bromodomain protein inhibitors in early stage clinical trials for acute myelogenous

RFC3 (1,502 words) [view diff] exact match in snippet view article find links to article

Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

RFC3 (1,502 words) [view diff] exact match in snippet view article find links to article

Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

IRF2 (1,192 words) [view diff] exact match in snippet view article find links to article

Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory

SMARCA4 (2,714 words) [view diff] exact match in snippet view article find links to article

A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex 2h60: Solution Structure of Human Brg1 Bromodomain

Phenotypic response surfaces (1,716 words) [view diff] exact match in snippet view article find links to article

AI platform has also been used to optimize a 2 drug combination of a bromodomain inhibitor and enzalutamide to successfully treat and prevent the progression

Chromosome 3 (1,991 words) [view diff] exact match in snippet view article find links to article

5-azacytidine-induced protein 2 BRK1: SCAR/WAVE actin nucleating complex subunit BRPF1: bromodomain and PHD finger containing 1 BTD: biotinidase C3orf14-Chromosome 3 open

Bookmarking (812 words) [view diff] exact match in snippet view article find links to article

Maruyama, T; Sciortino, S; Lippincott-Schwartz, J; Ozato, K (2000). "A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M

Danica Galonić Fujimori (710 words) [view diff] exact match in snippet view article find links to article

on virus-host interactions in response to SARS-CoV-2. She showed that bromodomain and extraterminal (BET) proteins were involved in the body's response

PTPN13 (1,227 words) [view diff] exact match in snippet view article find links to article

(1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6

Chromosome 21 (3,068 words) [view diff] exact match in snippet view article find links to article

transcription factor transcription regulator protein BACH1 BRWD1: encoding bromodomain and WD repeat-containing protein 1 BTG3: encoding protein BTG3 C21orf58:

HIST4H4 (946 words) [view diff] exact match in snippet view article find links to article

ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281

Stuart Conway (1,203 words) [view diff] exact match in snippet view article find links to article

His group reported inhibitors of the BET-bromodomain-containing proteins, the CREBBP and P300 bromodomains, and developed hypoxia-targeted pro-drugs

GATA1 (5,512 words) [view diff] exact match in snippet view article find links to article

Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA (May 2011). "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin

Myc (7,409 words) [view diff] exact match in snippet view article find links to article

(June 2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–36. doi:10.1016/j.molcel.2014

SERTAD1 (754 words) [view diff] exact match in snippet view article find links to article

Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1"

Cyclin-dependent kinase 8 (2,557 words) [view diff] exact match in snippet view article find links to article

association with components of Pol II mediator of a mammalian double-bromodomain protein". Molecular Endocrinology. 16 (8): 1727–37. doi:10.1210/me.2001-0353

MED17 (1,139 words) [view diff] exact match in snippet view article find links to article

PMC 528928. PMID 15489334. Jang MK, Mochizuki K, Zhou M, et al. (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates

Von Hippel–Lindau tumor suppressor (3,601 words) [view diff] exact match in snippet view article find links to article

(August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio

SIPA1 (723 words) [view diff] exact match in snippet view article find links to article

PMC 139241. PMID 12477932. Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity

Cyclin T2 (930 words) [view diff] exact match in snippet view article find links to article

Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates

SMARCA2 (1,564 words) [view diff] exact match in snippet view article find links to article

fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". Molecular & General Genetics. 248 (4): 491–8. doi:10.1007/BF02191650

Proteolysis targeting chimera (1,633 words) [view diff] exact match in snippet view article find links to article

(August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio

Chih-Ming Ho (1,674 words) [view diff] exact match in snippet view article find links to article

Drakaki, A., Belldegrun, A.S., Ho, C.M., and Ho, D., “Modulating BET Bromodomain Inhibitor ZEN-3694 and Enzalutamide Combination Dosing in a Metastatic

Ubiquitin ligase (4,461 words) [view diff] exact match in snippet view article find links to article

(2015-08-21). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio

HNRPUL1 (1,042 words) [view diff] exact match in snippet view article find links to article

ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281

RUNX3 (1,852 words) [view diff] exact match in snippet view article find links to article

response to growth factors, RUNX3 is acetylated by p300 to complex with bromodomain-containing protein 2 (BRD2; a member of the BET family of transcription

HIST3H2BB (944 words) [view diff] exact match in snippet view article find links to article

RM, et al. (2004). "Selective recognition of acetylated histones by bromodomain proteins visualized in living cells". Mol. Cell. 13 (1): 33–43. doi:10

TADA2L (1,104 words) [view diff] exact match in snippet view article find links to article

(Mar 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein

Ali Shilatifard (1,080 words) [view diff] exact match in snippet view article find links to article

Shilatifard, Ali (2017). "Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas". Nature Medicine. 23 (4):

TFDP1 (1,379 words) [view diff] exact match in snippet view article find links to article

Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1"

PAX3 (4,308 words) [view diff] exact match in snippet view article find links to article

2017). "PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability". primary. Cancer Discovery. 7 (8): 884–899. doi:10.1158/2159-8290

Ku70 (2,201 words) [view diff] exact match in snippet view article find links to article

(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein

Rhabdomyosarcoma (6,042 words) [view diff] exact match in snippet view article find links to article

(2017-08-01). "PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability". Cancer Discovery. 7 (8): 884–899. doi:10.1158/2159-8290

Proliferating cell nuclear antigen (6,180 words) [view diff] exact match in snippet view article find links to article

Cheong J, Bermudez VP, Tamura T, et al. (September 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression

ETV6 (4,620 words) [view diff] exact match in snippet view article find links to article

associated". Entrez Gene. "FCHO2 FCH domain only 2". Entrez Gene. "BAZ2A bromodomain adjacent to zinc finger domain 2A". Entrez Gene. Suto Y, Sato Y, Smith

H4K91ac (1,589 words) [view diff] exact match in snippet view article find links to article

to this mark although Pleckstrin homology domain's (PHIP) targetable bromodomain specifically binds H4K91ac which could implicate PHIP in the progression

MyoD (3,390 words) [view diff] exact match in snippet view article find links to article

Harel-Bellan A (August 2001). "Interaction between acetylated MyoD and the bromodomain of CBP and/or p300". Mol. Cell. Biol. 21 (16): 5312–20. doi:10.1128/MCB

Ku80 (2,612 words) [view diff] exact match in snippet view article find links to article

(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein

C7orf25 (683 words) [view diff] exact match in snippet view article find links to article

GC-Box factors SP1/GC 359 375 - HSF Heat shock factors 240 264 - BPTF Bromodomain and PHD domain transcription factors 423 433 + ZNF35 Zinc finger protein

TAF1 (2,426 words) [view diff] exact match in snippet view article find links to article

are often acetylated to open DNA for transcription. TAF1 contains two bromodomains, which each can bind one of two acetyllysine residues at position 5 and

HIST1H2AL (688 words) [view diff] exact match in snippet view article find links to article

ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281

Male contraceptive (15,359 words) [view diff] exact match in snippet view article find links to article

MN, Faver JC, et al. (March 2021). "Discovery and characterization of bromodomain 2-specific inhibitors of BRDT". Proceedings of the National Academy of

Epigenetics (18,275 words) [view diff] exact match in snippet view article find links to article

remodeler can then cause changes to the state of the chromatin. Indeed, a bromodomain – a protein domain that specifically binds acetyl-lysine – is found in

Alessio Ciulli (1,112 words) [view diff] exact match in snippet view article find links to article

which Ciulli and colleagues designed an engineered mutant variant of BET bromodomains able to accommodate selectively its binding ligand, enabling the individual

AI-10-49 (2,849 words) [view diff] exact match in snippet view article find links to article

activity, using a combined treatment with AI-10-49 and the BET-family bromodomain inhibitor JQ1, revealed a strong synergy in inv(16) AML cells and a significant

HIST2H4A (1,010 words) [view diff] exact match in snippet view article find links to article

"Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein". Mol. Cell. Biol. 23 (15): 5354–65. doi:10.1128/MCB

Steven A. Johnsen (3,112 words) [view diff] exact match in snippet view article find links to article

Chiang, Cheng-Ming; Grundhoff, Adam; Johnsen, Steven A. (2014-07-24). "Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation

JETLAG gene (1,496 words) [view diff] exact match in snippet view article find links to article

influence morning and evening activity in Drosophila. It also interacts with Bromodomain And WD Repeat Domain Containing 3 (BRWD3) and SKP1-related A (SkpA).

C17orf58 (682 words) [view diff] exact match in snippet view article find links to article

complex plays roles in cell proliferation and differentiation. BPTF bromodomain PHD finger transcription factor a complex which catalyzes ATP-dependent

Ali J. Marian (1,573 words) [view diff] exact match in snippet view article find links to article

Grazyna; Gurha, Priyatansh; Marian, Ali J. (September 1, 2020). "BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient

Stress granule (12,583 words) [view diff] exact match in snippet view article find links to article

Barrier-to-autointegration factor BAZ1B BAZ1B Bromodomain Adjacent To Zinc Finger Domain 1B BAZ2A BAZ2A Bromodomain Adjacent To Zinc Finger Domain 2A BCCIP

Facioscapulohumeral muscular dystrophy (16,498 words) [view diff] exact match in snippet view article find links to article

van der Maarel SM, Tapscott SJ, Sverdrup FM (4 September 2017). "BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified

Super-enhancer (6,635 words) [view diff] exact match in snippet view article find links to article

Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K (August 2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates

Cluster of Excellence Frankfurt Macromolecular Complexes (15,449 words) [view diff] exact match in snippet view article find links to article

freely available to researchers worldwide). CEF scientists have developed bromodomain inhibitors that can be used to study the function of these acetyl-lysine