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Longer titles found: Topoisomerase IV (view), Topoisomerase inhibitor (view), Type II topoisomerase (view), Type I topoisomerase (view), Anti-topoisomerase antibodies (view)

searching for Topoisomerase 125 found (665 total)

alternate case: topoisomerase

Facultative anaerobic organism (1,109 words) [view diff] exact match in snippet view article find links to article

(gyrA), while obligate anaerobes were defective in topoisomerase I (topI). This indicates that topoisomerase I and its associated relaxation of chromosomal

Methanopyrus (1,297 words) [view diff] exact match in snippet view article find links to article

Although topoisomerase V is useful in this case, finding other hyperthermophiles that have topoisomerase V has proven difficult. This lack of topoisomerase V

TOP2A (660 words) [view diff] exact match in snippet view article find links to article

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes

TOP3A (1,648 words) [view diff] exact match in snippet view article find links to article

DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene. This gene encodes a DNA topoisomerase, an enzyme that controls and

Labetuzumab govitecan (196 words) [view diff] exact match in snippet view article find links to article

antibody is covalently linked to SN-38, the active metabolite of the topoisomerase I inhibitor irinotecan. The drug was developed by Immunomedics, Inc

TOPBP1 (3,762 words) [view diff] exact match in snippet view article find links to article

DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein

NCAPH (1,276 words) [view diff] exact match in snippet view article find links to article

Molecular function protein binding chromatin binding DNA topoisomerase binding DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator

TOPORS (1,038 words) [view diff] exact match in snippet view article find links to article

Ahmed F, Su EW, Liu LF, Rubin EH (Jul 1999). "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein". Nucleic Acids Res

Aurora kinase B (4,544 words) [view diff] exact match in snippet view article find links to article

directly associated with the role of topoisomerase II in disjoining sister chromatids prior to anaphase. In topoisomerase II-depleted cells, Aurora B and INCENP

Epipodophyllotoxin (86 words) [view diff] exact match in snippet view article find links to article

etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase II. Podophyllotoxin Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy"

Phenanthridine (1,677 words) [view diff] exact match in snippet view article find links to article

phenanthridone's mutagenic effects. The two main mechanisms of action are: topoisomerase inhibition and DNA intercalation. Phenanthridine derivatives have

Regulatory sequence (4,306 words) [view diff] exact match in snippet view article find links to article

in enhancers appear to depend on double-strand breaks initiated by topoisomerase 2β (TOP2B) for activation. The induction of particular double-strand

Nucleolin (1,944 words) [view diff] exact match in snippet view article find links to article

Rubin EH (Apr 1998). "Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen". Nucleic Acids Research. 26 (7): 1841–7

Lidia Rudnicka (3,334 words) [view diff] exact match in snippet view article find links to article

etiology of systemic sclerosis to a mutation in the topoisomerase I gene and abnormal topoisomerase I expression. She believes that presence of anti-topoisomerse

Antibiotic resistance in gonorrhea (1,703 words) [view diff] exact match in snippet view article find links to article

have also been noted in the parC gene which encodes for the topoisomerase IV. Topoisomerase IV acts similarly to DNA gyrase and is involved in unwinding

UHRF1 (3,306 words) [view diff] exact match in snippet view article find links to article

G1/S transition, it has been reported to influence the expression of topoisomerase IIα and the retinoblastoma gene. It also functions in the p53-dependent

Acutissimin A (242 words) [view diff] exact match in snippet view article find links to article

Jourdes M, Saucier C, Glories Y, Pardon P, Baudry C (December 2003). "DNA topoisomerase inhibitor acutissimin a and other flavano-ellagitannins in red wine"

Bloom syndrome protein (2,569 words) [view diff] exact match in snippet view article find links to article

during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha". Nucleic Acids Res. 29 (15): 3172–80. doi:10.1093/nar/29.15

Memory (17,398 words) [view diff] exact match in snippet view article find links to article

learned. Such genes are referred to as immediate early genes (IEGs). DNA topoisomerase 2-beta (TOP2B) activity is essential for the expression of IEGs in a

GHKL domain (437 words) [view diff] exact match in snippet view article find links to article

several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch

HLA-DR11 (829 words) [view diff] exact match in snippet view article find links to article

Hepatitis C. DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB

SR protein (3,443 words) [view diff] exact match in snippet view article find links to article

binding to the coding DNA strand to increase genome stabilization. Topoisomerase I and SR proteins also interact to increase genome stabilization. SR

Mark Cushman (2,904 words) [view diff] exact match in snippet view article find links to article

was discovered the indenoisoquinolines inhibited the action of the topoisomerase I enzyme. Later, it was found these molecules can also affect other

Crithidia fasciculata (738 words) [view diff] exact match in snippet view article find links to article

indicate that Topoisomerase II has decatenated the kinetoplasts. This assay can be used to determine whether drugs or toxins that target Topoisomerase II are

Nondisjunction (2,922 words) [view diff] exact match in snippet view article find links to article

nondisjunction in mitosis can be attributed to the inactivation of topoisomerase II, condensin, or separase. Meiotic nondisjunction has been well studied

HLA-DR16 (854 words) [view diff] exact match in snippet view article find links to article

2007-08-07 at the Wayback Machine, systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody, melioidosis (Burkholderia pseudomallei infection)

60S ribosomal protein L41 (1,691 words) [view diff] exact match in snippet view article find links to article

of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. The main functions are to enable mRNA 3’-UTR binding

Aurintricarboxylic acid (522 words) [view diff] exact match in snippet view article find links to article

protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates

Serine/arginine-rich splicing factor 1 (2,590 words) [view diff] exact match in snippet view article find links to article

(Jun 1998). "Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation

SETMAR (1,594 words) [view diff] exact match in snippet view article find links to article

DNA binding single-stranded DNA endodeoxyribonuclease activity DNA topoisomerase binding protein binding catalytic activity nuclease activity endonuclease

4-Nitroquinoline 1-oxide (765 words) [view diff] exact match in snippet view article find links to article

macromolecules such as nucleic acids and proteins. 4NQO has been shown to trap topoisomerase I cleavage complexes. It may also induce DNA damage through the production

BTBD2 (764 words) [view diff] exact match in snippet view article find links to article

BTBD2 gene. The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain

BTBD2 (764 words) [view diff] exact match in snippet view article find links to article

BTBD2 gene. The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain

4-Nitroquinoline 1-oxide (765 words) [view diff] exact match in snippet view article find links to article

macromolecules such as nucleic acids and proteins. 4NQO has been shown to trap topoisomerase I cleavage complexes. It may also induce DNA damage through the production

Fostriecin (1,217 words) [view diff] exact match in snippet view article find links to article

inhibitor of protein serine/threonine phosphatases, as well as DNA topoisomerase II. Due to its activity against protein phosphatases PP2A and PP4 (IC50

Morphea (1,528 words) [view diff] exact match in snippet view article find links to article

morphea have shown results in higher frequencies of anti-histone and anti-topoisomerase IIa antibodies. Case reports of morphea co-existing with other systemic

Sgs1 (392 words) [view diff] exact match in snippet view article find links to article

in mammals. Gangloff, S; et al. (December 1994). "The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic

Podophyllotoxin (2,450 words) [view diff] exact match in snippet view article find links to article

contrast, some of its derivatives display binding activity to the enzyme topoisomerase II (Topo II) during the late S and early G2 stages. For instance, etoposide

TopoTarget (2,966 words) [view diff] exact match in snippet view article find links to article

works by inhibiting DNA topoisomerase II, which is the target of anthracycline chemotherapy. The drug binds to DNA topoisomerase II at a different step

Distamycin (437 words) [view diff] exact match in snippet view article find links to article

Distamycin inhibits the transcription and increases the activity of the topoisomerase II. Derivates from distamycin are used as alkylating antineoplastic

Pinacolone (389 words) [view diff] exact match in snippet view article find links to article

Oda, T; Sato, Y; Kodama, M; Kaneko, M (July 1993). "Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues". Biological & Pharmaceutical

Paphiopedilum callosum (404 words) [view diff] exact match in snippet view article find links to article

study in 2020 discovered a novel stilbenoid, which was identified as a topoisomerase I inhibitor, with varying degrees of cytotoxicity towards human cancer

ATM serine/threonine kinase (5,695 words) [view diff] exact match in snippet view article find links to article

by DNA double-strand breaks (canonical pathway), oxidative stress, topoisomerase cleavage complexes, splicing intermediates, R-loops and in some cases

Drug resistance (3,055 words) [view diff] exact match in snippet view article find links to article

to 50S ribosome subunit, inhibiting protein synthesis Binds to DNA topoisomerase, an enzyme essential for DNA synthesis Binds to the RNA polymerase;

Daniel Hochhauser (492 words) [view diff] exact match in snippet view article find links to article

C.; Mantovani, R.; Lee, M.; Hartley, J. A. (2007). "Modulation of topoisomerase II expression by a DNA sequence-specific polyamide" (PDF). Molecular

Conrad–Limpach synthesis (1,046 words) [view diff] exact match in snippet view article find links to article

ability to kill bacteria. This mechanism involved disabling the bacterial topoisomerase II/IV enzyme (the target in most Gram-positive bacteria) or DNA gyrase

Abituzumab (974 words) [view diff] exact match in snippet view article find links to article

targets epidermal growth factor receptor (EGFR), and irinotecan, a topoisomerase I inhibitor, can be used in combination as standard of care for treating

Phospholipid scramblase 1 (1,146 words) [view diff] exact match in snippet view article find links to article

plasma membrane phospholipid scrambling positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity response to interferon-beta regulation of

UBE2I (2,840 words) [view diff] exact match in snippet view article find links to article

Liu LF (April 2000). "SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage". Proc. Natl. Acad. Sci.

Olympic gel (459 words) [view diff] exact match in snippet view article find links to article

construction of Olympic gels from DNA in various ways. One method uses Topoisomerase II to form links between circular molecules such as plasmids, which

James Champoux (306 words) [view diff] exact match in snippet view article find links to article

University. His interests were retroviruses and topoisomerases and his highest cited paper is DNA Topoisomerases: Structure, Function, and Mechanism at 2260

Ifinatamab deruxtecan (269 words) [view diff] exact match in snippet view article find links to article

conjugate that "consists of an anti-B7-H3 antibody linked with a DNA topoisomerase I inhibiting anti-tumor agent". Ifinatamab-DXd is in phase III clinical

SFPQ (1,265 words) [view diff] exact match in snippet view article find links to article

Boege F (Oct 1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". The Journal of Biological Chemistry

UBR5 (1,223 words) [view diff] exact match in snippet view article find links to article

(Feb 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5):

UBR5 (1,223 words) [view diff] exact match in snippet view article find links to article

(Feb 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5):

SUMO protein (5,013 words) [view diff] exact match in snippet view article find links to article

associated with mitotic chromosomes arose from SUMO-2/3 conjugation of topoisomerase II, which is modified exclusively by SUMO-2/3 during mitosis. SUMO-2/3

Carbazole (1,022 words) [view diff] exact match in snippet view article find links to article

and the veterinary NSAID Carprofen are all made from carbazole. The topoisomerase II inhibitor ellipticine fuses carbazole to a pyridine ring. Indole

Antibody–drug conjugate (4,234 words) [view diff] exact match in snippet view article find links to article

monomethyl auristatin F (MMAF) and mertansine, DNA binder calicheamicin and topoisomerase 1 inhibitors SN-38 and exatecan resulting in a renaissance for natural

TATA box (4,754 words) [view diff] exact match in snippet view article find links to article

contain such compounds include topotecan, SN-38 (topoisomerase I), doxorubicin, and mitoxantrone (topoisomerase II). Cisplatin is a compound that binds covalently

Ataxia–telangiectasia (10,879 words) [view diff] exact match in snippet view article find links to article

development Transcription stress and abortive transcription including topoisomerase 1 cleavage complex (TOP1cc) dependent lesions Aneuploidy Defective response

Kathleen I. Pritchard (2,513 words) [view diff] exact match in snippet view article find links to article

with normal HER-2/neu levels. The target of anthracycline drugs is topoisomerase II, and its location in regards to the HER-2 gene on the chromosome

HDAC1 (5,403 words) [view diff] exact match in snippet view article find links to article

E (November 2000). "Histone deacetylase interacts directly with DNA topoisomerase II". Nature Genetics. 26 (3): 349–353. doi:10.1038/81671. PMID 11062478

RNA Helicase A (1,658 words) [view diff] exact match in snippet view article find links to article

cellular response to tumor necrosis factor positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity regulation of cytoplasmic translation positive

T-cell surface glycoprotein CD3 epsilon chain (1,591 words) [view diff] exact match in snippet view article find links to article

Nozaki N, Kikuchi A, Saito T (March 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". The

Genetic transformation (6,913 words) [view diff] exact match in snippet view article find links to article

agents mitomycin C (a DNA cross-linking agent) and fluoroquinolone (a topoisomerase inhibitor that causes double-strand breaks). In B. subtilis, transformation

HLA-DR52 (884 words) [view diff] exact match in snippet view article find links to article

(1993). "The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma)". J. Clin. Invest. 92 (3): 1296–301

Non-POU domain-containing octamer-binding protein (2,478 words) [view diff] exact match in snippet view article find links to article

et al. (October 1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". The Journal of Biological Chemistry

HNRPU (1,291 words) [view diff] exact match in snippet view article find links to article

glucocorticoid stimulus RNA localization to chromatin positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of stem cell proliferation

Olivetolic acid (220 words) [view diff] exact match in snippet view article find links to article

"Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor". PLOS ONE. 8 (4) e60770. Bibcode:2013PLoSO...860770C

Fungal isolate (966 words) [view diff] exact match in snippet view article find links to article

fungus antiinflammatory, inhibitory activity of DNA polymerases and DNA topoisomerase II, active synthetic analogs Epoxyagroclavine permafrost Penicillium

Bill Earnshaw (1,017 words) [view diff] exact match in snippet view article find links to article

563000. Petruti-Mot, Anca (2000). Genetic and functional analysis of topoisomerase II in vertebrates (PhD thesis). University of Edinburgh. hdl:1842/8985

Gordon Hammes (1,027 words) [view diff] exact match in snippet view article find links to article

measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II". Proceedings of the National Academy of Sciences. 104 (12): 4840–4845

CENPF (1,346 words) [view diff] exact match in snippet view article find links to article

Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7

Chromosomal fragile site (2,524 words) [view diff] exact match in snippet view article find links to article

antibiotic aphidicolin (APH). Co-treatment with low concentrations of the topoisomerase I inhibitor, camptothecin (CPT), reduces APH-induced breakage. CFS regions

Sandmeyer reaction (1,746 words) [view diff] exact match in snippet view article find links to article

synthesis of neoamphimedine, a compound that is suggested to target topoisomerase II as an anti-cancer drug. It has been demonstrated that Sandmeyer-type

ERCC excision repair 6 like, spindle assembly checkpoint helicase (669 words) [view diff] exact match in snippet view article find links to article

HH, Mills W, Carpenter AJ, Porter AC, Farr CJ (2007). "Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance

Nektar Therapeutics (640 words) [view diff] exact match in snippet view article find links to article

(Movantik), a Phase III oral opioid antagonist, etirinotecan pegol, a topoisomerase inhibitor under Phase III clinical study as of 2012, NKTR 061, NKTR-181

Ribose-seq (4,617 words) [view diff] exact match in snippet view article find links to article

methods include incisions that are mediated by the isomerase enzyme, topoisomerase I. If not removed and replaced, ribonucleotides in DNA can have structural

Topopyrone C (68 words) [view diff] exact match in snippet view article find links to article

Iwatani, W; Iwatani, W; Konno, H; Kanazawa, S (2000). "Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. II. Structure elucidation"

Werner syndrome helicase (3,936 words) [view diff] exact match in snippet view article find links to article

pyrimidines, or mitomycin C, but are sensitive to type I and type II topoisomerase inhibitors. These findings suggested that the WRN protein takes part

University of Kalyani (1,313 words) [view diff] exact match in snippet view article find links to article

effect against liver cancer cells in vitro by modulating telomerase and topoisomerase II activities as also by promoting apoptosis via intrinsic mitochondrial

Caspase 6 (1,632 words) [view diff] exact match in snippet view article find links to article

Kaufmann SH, Earnshaw WC (1999). "Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis". J. Biol. Chem. 274 (7):

Dragon's blood (1,651 words) [view diff] exact match in snippet view article find links to article

Olofsson, MH; Larsson, R; Linder, S (2009). "Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters"

Spindle apparatus (3,312 words) [view diff] exact match in snippet view article find links to article

incomplete. A few specific molecular players have been identified, however: Topoisomerase II uses ATP hydrolysis to catalyze decatenation of DNA entanglements

Ophiorrhiza (447 words) [view diff] exact match in snippet view article find links to article

Sirikantaramas, Supaart; Yamazaki, Mami; Saito, Kazuki (2008). "Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the

Large tumor antigen (2,171 words) [view diff] exact match in snippet view article find links to article

protein-protein interactions with host cell proteins, most notably topoisomerase 1 and the cell cycle regulator p53. LTag is unique among known AAA+

Daiichi Sankyo (2,402 words) [view diff] exact match in snippet view article find links to article

"Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models"

Follicular dendritic cell sarcoma (2,551 words) [view diff] exact match in snippet view article find links to article

with cell growth and replication by intercalating in DNA. This stops topoisomerase II from relaxing the DNA strands and inhibits transcription. Recent

Haloarchaea (2,920 words) [view diff] exact match in snippet view article find links to article

Haloarchaea. These CSIs are present in the following proteins: DNA topoisomerase VI, nucleotide sugar dehydrogenase, ribosomal protein L10e, RecJ-like

Suramin (2,172 words) [view diff] exact match in snippet view article find links to article

(PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). "Suramin Injection

Breast cancer classification (9,475 words) [view diff] exact match in snippet view article find links to article

affected by DNA assays that predict relative resistance or sensitivity. Topoisomerase II (TOP2A) expression predicts whether doxorubicin is relatively useful

Mutagenesis (4,380 words) [view diff] exact match in snippet view article find links to article

daunorubicin and doxorubicin interferes with the functioning of the enzyme topoisomerase II, blocking replication as well as causing mitotic homologous recombination

GTF3C1 (796 words) [view diff] exact match in snippet view article find links to article

1016/S0021-9258(18)35787-9. PMID 1447193. Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination

GTF3C2 (1,109 words) [view diff] exact match in snippet view article find links to article

1093/nar/25.12.2440. PMC 146769. PMID 9171097. Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination

Angelman syndrome (5,555 words) [view diff] exact match in snippet view article find links to article

inactive in neurons because the UBE3A-ATS RNA transcript silences it. The topoisomerase inhibitor topotecan is effective at unsilencing paternal UBE3A throughout

FBLN5 (1,401 words) [view diff] exact match in snippet view article find links to article

Kobayashi M, Hanai R (Sep 2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochemical and Biophysical Research Communications

Mutagenesis (4,380 words) [view diff] exact match in snippet view article find links to article

daunorubicin and doxorubicin interferes with the functioning of the enzyme topoisomerase II, blocking replication as well as causing mitotic homologous recombination

GTF3C1 (796 words) [view diff] exact match in snippet view article find links to article

1016/S0021-9258(18)35787-9. PMID 1447193. Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination

GT198 (2,345 words) [view diff] exact match in snippet view article find links to article

aminolevulinic acid. GT198 has protein sequence homology with DNA topoisomerase, so that DNA topoisomerase inhibitors are also GT198 inhibitors. Interestingly, several

TRIM41 (417 words) [view diff] exact match in snippet view article find links to article

Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7

Scaffold protein (2,159 words) [view diff] exact match in snippet view article find links to article

chromosome. Chromosome scaffold is made of proteins including condensin, topoisomerase IIα and kinesin family member 4 (KIF4) Chromosome scaffold constituent

PCSK4 (572 words) [view diff] exact match in snippet view article find links to article

95.5.2192. PMC 19292. PMID 9482861. Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination

Acute myeloid leukemia (8,414 words) [view diff] exact match in snippet view article find links to article

developing AML. Other chemotherapy agents, including fludarabine, and topoisomerase II inhibitors are also associated with the development of AML; most

Enterococcus faecalis (3,519 words) [view diff] exact match in snippet view article find links to article

hydroxymethylglutaryl-CoA synthase, diphosphomevalonate decarboxylase, topoisomerase DNA gyrase B, D-alanine—D-serine ligase, alanine racemase, phosphate

Acute promyelocytic leukemia (3,656 words) [view diff] exact match in snippet view article find links to article

occur as a secondary malignancy in those that receive treatment with topoisomerase II inhibitors (such as the anthracyclines and etoposide) due to the

Cestrum nocturnum (1,544 words) [view diff] exact match in snippet view article find links to article

Apoptosis in Malignant Cells through Inducing DNA Damage and Inhibiting Topoisomerase II Activity". Evidence-Based Complementary and Alternative Medicine

Nanomedicine (5,920 words) [view diff] exact match in snippet view article find links to article

"Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts"

IMPDH2 (1,116 words) [view diff] exact match in snippet view article find links to article

Peñuelas S, Noé V, Ciudad CJ (2005). "Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon

Lamellarin D (499 words) [view diff] exact match in snippet view article find links to article

strong cytotoxic activity against tumor cell lines, and is a potent topoisomerase I inhibitor. The lamellarins all contain a central pyrrole ring, substituted

Granzyme B (2,039 words) [view diff] exact match in snippet view article find links to article

retroviral DNA integration. Granzyme B can also cleave nucleophosmin, topoisomerase 1 and nucleolin to prevent viral replication. Granzyme B can cleave

Synergy (6,174 words) [view diff] exact match in snippet view article find links to article

thereby preventing the cell from replicating DNA. Irinotecan inhibits topoisomerase 1, consequently the cytostatic effect is increased. Effect on the same

Mariel Vázquez (558 words) [view diff] exact match in snippet view article find links to article

January 2018. Vazquez, Mariel. "Computer Analysis of DNA Unknotting by Topoisomerase (pilot)". Grantome. Retrieved 14 January 2018. "Vazquez to Receive 2016

Lunasia (546 words) [view diff] exact match in snippet view article find links to article

Sutherland K. (2007). "Lunacridine from Lunasia amara is a DNA intercalating topoisomerase II inhibitor". Journal of Ethnopharmacology. 109 (2): 289–294. doi:10

GLI1 (2,311 words) [view diff] exact match in snippet view article find links to article

Checkpoint in Tumor Cells via Bid and its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors". Journal of Biological Chemistry. 289 (45): 31513–25.

Solibacillus (621 words) [view diff] exact match in snippet view article find links to article

hook–basal body protein, aminodeoxychorismate lyase, VOC family protein, DNA topoisomerase IV subunit A, DegV family protein, helicase–exonuclease AddAB subunit

P-glycoprotein (3,959 words) [view diff] exact match in snippet view article find links to article

desloratadine, tacrolimus and quinidine. Chemotherapeutic agents such as topoisomerase inhibitors (i.e. etoposide, doxorubicin), microtubule-targeted drugs

GRWD1 (669 words) [view diff] exact match in snippet view article find links to article

2002). "Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display". Molecular Biology Reports. 29 (4): 347–352

Hartmann F. Stähelin (1,801 words) [view diff] exact match in snippet view article find links to article

furthermore, both drugs act via an effect on an intranuclear isomerase, topoisomerase II, and peptide cis-trans-isomerase, respectively; both compounds are

GAS7 (545 words) [view diff] exact match in snippet view article find links to article

leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2814–2819. Bibcode:2000PNAS

SMURF2 (1,326 words) [view diff] exact match in snippet view article find links to article

Levy-Cohen G, Blank M (Aug 2017). "Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity". Cancer Research. 77 (16): 4217–4227

Pittosporum angustifolium (1,450 words) [view diff] exact match in snippet view article find links to article

Preissner, Robert; Lindequist, Ulrike (1 April 2016). "Inhibition of DNA–Topoisomerase I by Acylated Triterpene Saponins from Pittosporum angustifolium Lodd"

Adenylylation (3,314 words) [view diff] exact match in snippet view article find links to article

the conserved tyrosine residue for ATP binding of ParE subunit at Topoisomerase IV. This DNA gyrase inactivation by AMPylation leads to the activation

SUMO1 (2,334 words) [view diff] exact match in snippet view article find links to article

Y, Desai SD, Liu LF (August 2000). "SUMO-1 conjugation to human DNA topoisomerase II isozymes". The Journal of Biological Chemistry. 275 (34): 26066–73

Fervidobacterium islandicum (968 words) [view diff] exact match in snippet view article find links to article

Patrick; Huber, Robert; Duguet, Michel (1993). "ATP-independent DNA topoisomerase from Fervidobacterium islandicum". Biochimica et Biophysica Acta (BBA)

PARP2 (1,307 words) [view diff] exact match in snippet view article find links to article

Althaus FR (February 2004). "Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing". The Journal of Biological