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searching for MTOR 146 found (892 total)

alternate case: mTOR

RHEB (2,680 words) [view diff] exact match in snippet view article find links to article

expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle. RHEB is a member of the Ras

Akt/PKB signaling pathway (4,079 words) [view diff] exact match in snippet view article find links to article

feedback loop. Akt promotes cyclin D1 translation via indirect activation of mTOR. mTOR increases translation of cyclin D1 by activating ribosomal protein S6K

MLST8 (810 words) [view diff] exact match in snippet view article find links to article

subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and

EIF4EBP1 (2,697 words) [view diff] exact match in snippet view article find links to article

Phosphorylated 4E-BP1 is thought to be a marker of upstream signaling (mTOR) activation. 4E-BP1 has seven phospho-sites, the three most important of

Stuart Schreiber (3,533 words) [view diff] exact match in snippet view article find links to article

“molecular glues” that promote protein–protein interactions, the co-discovery of mTOR and its role in nutrient-response signaling, the discovery of histone deacetylases

Geraniin (446 words) [view diff] exact match in snippet view article find links to article

anticancer activity and shown to target apoptosis via inactivation of PI3K/Akt/mTOR signaling pathway involving NF-κB when treated against HT-29 human colorectal

DEPTOR (859 words) [view diff] exact match in snippet view article find links to article

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by

Farnesyltransferase inhibitor (1,086 words) [view diff] exact match in snippet view article find links to article

molecules are called FTIs (or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were

TSC2 (1,801 words) [view diff] exact match in snippet view article find links to article

Cantley LC (July 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. PMID 15261145

Eukaryotic initiation factor 3 (2,101 words) [view diff] exact match in snippet view article find links to article

cellular signaling through S6K1 and mTOR/Raptor. In particular, eIF3 is bound by S6K1 in its inactive state, and activated mTOR/Raptor binds to eIF3 and phosphorylates

1-α-O-Galloylpunicalagin (140 words) [view diff] exact match in snippet view article find links to article

production in a dose-dependent manner in endothelial cells via the PI3K/AKT/mTOR pathway. Combreglutinin, a Hydrolyzable Tannin from Combretum glutinosum

Tuberous sclerosis (5,517 words) [view diff] exact match in snippet view article find links to article

An mTOR inhibitor drug can help, though a lung transplant may be required. A 12-lead ECG should be performed every three to five years. The mTOR inhibitor

Perifosine (398 words) [view diff] exact match in snippet view article find links to article

structurally related to miltefosine. Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin

Ovarian follicle activation (4,015 words) [view diff] exact match in snippet view article find links to article

primordial follicles. It does this by negatively controlling the PI3K/AKT/mTOR pathway. This particular action of PTEN was initially discovered in an experiment

Folliculin (5,618 words) [view diff] exact match in snippet view article find links to article

regulator of mechanistic target of rapamycin (mTOR) suggesting that FLCN and FNIP1 may play a role in modulating mTOR activity through energy- or nutrient-sensing

Koenen's tumor (1,378 words) [view diff] exact match in snippet view article find links to article

e. mTOR) protein that promotes cell growth and proliferation. Inactivation of one of the TSC1 or TSC2 genes appears responsible for unleashing mTor and

PEST sequence (1,540 words) [view diff] exact match in snippet view article find links to article

the PI3K/AKT/mTOR pathway. This correlation becomes particularly relevant in lung adenocarcinoma cells, as the upregulation of PI3K/AKT/mTOR in these cells

Papillary hidradenoma (2,440 words) [view diff] exact match in snippet view article find links to article

production of proteins that directly or indirectly stimulate the PI3K/AKT/mTOR intracellular signaling pathway. The mutated genes include PIK3CA, AKT1,

Tuberous sclerosis protein (1,058 words) [view diff] exact match in snippet view article find links to article

acts as an important integrator of different signaling pathways controlling mTOR signaling, by regulating especially mTORC1 activity. TSC2 contains a GTPase

EIF4E (7,714 words) [view diff] exact match in snippet view article find links to article

et al. (2015-08-28). Eaves CJ (ed.). "Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase

EIF3B (952 words) [view diff] exact match in snippet view article find links to article

9 eta, 116kDa". Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through

ATC code L01 (969 words) [view diff] no match in snippet view article find links to article

ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes

Phosphatidylinositol-4,5-bisphosphate 3-kinase (298 words) [view diff] case mismatch in snippet view article find links to article

metabolism, erbb signaling pathway, phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like

Phakomatosis (7,009 words) [view diff] exact match in snippet view article find links to article

the RAS–mitogen-activated protein kinase (MAPK) pathway and the PI3K/AKT/mTOR pathway that regulates cellular growth, differentiation, proliferation and

BTRC (gene) (3,356 words) [view diff] exact match in snippet view article

for the ribosome. βTrCP also cooperates with mTOR and CK1α to induce the degradation of DEPTOR (an mTOR inhibitor), thereby generating an auto-amplification

Aglycone (448 words) [view diff] exact match in snippet view article find links to article

performance of mice. The aglycone-fed mice displayed strong autophagic reactions, mTOR regulation, and reduced plaque deposits and β-amyloid levels. Glucoside McNaught

BTRC (gene) (3,356 words) [view diff] exact match in snippet view article

for the ribosome. βTrCP also cooperates with mTOR and CK1α to induce the degradation of DEPTOR (an mTOR inhibitor), thereby generating an auto-amplification

XL-388 (329 words) [view diff] exact match in snippet view article find links to article

selective inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for the treatment of various

Caloric restriction mimetic (2,851 words) [view diff] exact match in snippet view article find links to article

Rapamycin (mTOR) pathway, might be a CR mimetic. based on the responsiveness of mTORC1 activity to nutrient availability; the fact that mTOR activity is

JAK-STAT signaling pathway (6,845 words) [view diff] exact match in snippet view article find links to article

to interconnect with other cell-signalling pathways, such as the PI3K/AKT/mTOR pathway. When JAKs are activated and phosphorylate tyrosine residues on receptors

Eukaryotic initiation factor (1,593 words) [view diff] exact match in snippet view article find links to article

their translation. eIF3 also mediates cellular signaling through S6K1 and mTOR/Raptor to effect translational regulation. The eIF4F complex is composed

FBXW11 (3,045 words) [view diff] exact match in snippet view article find links to article

translation and cell growth. βTrCP also cooperates with mTOR and CK1α to induce the degradation of DEPTOR (an mTOR inhibitor), thereby generating an auto-amplification

PIK3IP1 (677 words) [view diff] exact match in snippet view article find links to article

transmembrane protein that binds to PI3K, reducing signal to the PI3K/AKT/mTOR pathway. Through this mechanism, PIK3IP1 inhibits cell proliferation in tumor

EIF4B (1,793 words) [view diff] exact match in snippet view article find links to article

Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, et al. (Jun 2006). "The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and

SR protein (3,443 words) [view diff] exact match in snippet view article find links to article

transcripts to auto-regulate the concentration of SR proteins. Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation

Brian K. Kennedy (897 words) [view diff] exact match in snippet view article find links to article

Kaeberlein, he published seminal reports identifying the importance of the mTOR pathway in regulating longevity. In 2010, joined the Buck Institute for Research

LAMTOR4 (83 words) [view diff] exact match in snippet view article find links to article

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 is a protein that in humans is encoded by the LAMTOR4 gene. GRCh38: Ensembl release 89: ENSG00000188186

Interleukin 27 (668 words) [view diff] exact match in snippet view article find links to article

inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected

HY-124798 (337 words) [view diff] exact match in snippet view article find links to article

acts as an endogenous activator of the mechanistic target of rapamycin (mTOR) subtype mTORC1. Since many of the side effects of rapamycin and its analogues

Kun-Liang Guan (667 words) [view diff] exact match in snippet view article find links to article

the mammalian target of rapamycin (mTOR), which is a central cell growth controller conserved from yeast to human. mTOR integrates a wide range of signals

Arlan Richardson (1,404 words) [view diff] exact match in snippet view article find links to article

stress, Richardson explored the role of the mammalian target of rapamycin (mTOR) pathway, showing that its inhibition by rapamycin extends lifespan in mice

Endometrial cancer (10,863 words) [view diff] exact match in snippet view article find links to article

inhibit the mTOR pathway may reduce the risk of disease worsening compared to having more chemotherapy or hormonal therapy. However, mTOR inhibitors may

MEK inhibitor (720 words) [view diff] exact match in snippet view article find links to article

Kathy (2016-11-29). "In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC". Oncotarget. 7 (48): 79526–79543

Midkine (2,496 words) [view diff] exact match in snippet view article find links to article

versus WT cells, seemed to activate PKB (Akt), mTOR, and Bad protein, while it inactivated caspase-3. PKB, mTOR, and Bad are all elements associated with the

Signal transducing adaptor protein (697 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Lhermitte–Duclos disease (518 words) [view diff] exact match in snippet view article find links to article

in PTEN gene on chromosome no. 10q leads to increased activity of AKT and mTOR pathways, and patients should be tested for these mutations because they

Tumor metabolome (2,597 words) [view diff] exact match in snippet view article find links to article

The protein AKT1 (also known as Protein Kinase B or PKB) in the PI3K/AKT/mTOR pathway is an important driver of the tumor glycolytic phenotype and stimulates

Exon junction complex (2,530 words) [view diff] exact match in snippet view article find links to article

speckled domains has been measured recently and it may be regulated by PI3K/AKT/mTOR signaling pathways. In order for the binding of the complex to the mRNA to

Ketogenic amino acid (821 words) [view diff] exact match in snippet view article find links to article

(December 2004). "Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from

Eukaryotic translation initiation factor 4 gamma 1 (1,672 words) [view diff] exact match in snippet view article find links to article

synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Molecular and Cellular Biology. 26

WYE-687 (202 words) [view diff] exact match in snippet view article find links to article

as an inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in

Follicular dendritic cell sarcoma (2,551 words) [view diff] exact match in snippet view article find links to article

studies have also shown that doxorubicin may be involved in the PI3K/AKT/mTOR pathway. An important hallmark of cancer, Akt is part of the cell survival

U0126 (743 words) [view diff] exact match in snippet view article find links to article

extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR)-p70(S6K) pathways. U0126 is selective for MEK and has little to no effect

FRS2 (1,857 words) [view diff] exact match in snippet view article find links to article

multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. It is overexpressed and amplified in several cancer types

UBQLN1 (1,428 words) [view diff] exact match in snippet view article find links to article

including UBQLN2 and UBQLN4. UBQLN1 has been shown to interact with HERPUD1, MTOR, P4HB, PSEN1 PSEN2, and UBE3A. TMCO6, GRCh38: Ensembl release 89: ENSG00000135018

MiR-218 microRNA precursor family (477 words) [view diff] exact match in snippet view article find links to article

J (September 2011). "The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer". Cancer

CAD protein (1,164 words) [view diff] exact match in snippet view article find links to article

"Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1". Science. 339 (6125): 1323–8. Bibcode:2013Sci...339.1323B. doi:10

Autoimmune lymphoproliferative syndrome (2,504 words) [view diff] exact match in snippet view article find links to article

replacement.[citation needed] Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor can be active in most patients

Manlio Vinciguerra (169 words) [view diff] exact match in snippet view article find links to article

processes, stress and aging in the heart and in the liver, such as the PI3K/AKT/mTOR pathway, histone variants and sirtuins, using a systems biology approach

Muscle hypertrophy (5,314 words) [view diff] exact match in snippet view article find links to article

mechanical tension. Mechanical tension is known to activate pathways such as mTOR, which is responsible for protein synthesis, a mechanism that directly contributes

Exercise (10,770 words) [view diff] exact match in snippet view article find links to article

"The neurology of mTOR". Neuron. 84 (2): 275–291. doi:10.1016/j.neuron.2014.09.034. PMC 4223653. PMID 25374355. Figure 2: The mTOR Signaling Pathway Wang

Contact inhibition (2,207 words) [view diff] exact match in snippet view article find links to article

contact-inhibited cells must activate growth-activating pathways such as mTOR. Once cells in high-density cultures become confluent enough such that the

Contact inhibition (2,207 words) [view diff] exact match in snippet view article find links to article

contact-inhibited cells must activate growth-activating pathways such as mTOR. Once cells in high-density cultures become confluent enough such that the

Disposable soma theory of aging (4,338 words) [view diff] exact match in snippet view article find links to article

chaperones, and heat-shock proteins. Additionally, uptake of IGF-1 stimulates the mTOR pathway, which activates protein synthesis (and therefore growth) through

Immunosuppression (938 words) [view diff] exact match in snippet view article find links to article

immunodeficiency of T-cells. Immunosuppressive drug Discovery and development of mTOR inhibitors BK virus Interleukin-2 immunotherapy B cell deficiency T cell

AU-rich element (2,911 words) [view diff] exact match in snippet view article find links to article

The RNA binding protein DDX21 has been reported to bind to AREs and confer mTOR-mediated translation control of cytokines during T cell activation. AREsite—a

Peroxiredoxin 1 (1,698 words) [view diff] exact match in snippet view article find links to article

that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma. The expression patterns

Phosphorylation (1,862 words) [view diff] exact match in snippet view article find links to article

(October 2007). "Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart". Cardiovascular Research. 76 (1): 71–80. doi:10

Cobimetinib (921 words) [view diff] exact match in snippet view article find links to article

et al. (November 2016). "In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC". Oncotarget. 7 (48): 79526–79543

STAT3 (3,493 words) [view diff] exact match in snippet view article find links to article

shown to interact with: AR, ELP2, EP300, EGFR, HIF1A, JAK1, JUN KHDRBS1, mTOR, MYOD1, NDUFA13, NFKB1, NR3C1, NCOA1, PML, RAC1, RELA, RET, RPA2, STAT1,

Fayaz A. Malik (1,634 words) [view diff] exact match in snippet view article find links to article

Suresh; Katoch, Meenu; Bhushan, Shashi (2013). "Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential

Lipofibromatosis (1,860 words) [view diff] exact match in snippet view article find links to article

proto-oncogene receptor, respectively, all of which activate the PI3K/AKT/mTOR pathway; 2) the BRAF and ROS1 genes code for serine/threonine-protein kinase

Psychopharmacology (4,686 words) [view diff] exact match in snippet view article find links to article

the relative spike in glutamate levels, as well as its interaction with mTOR, which is an enzymatic protein involved in catabolic processes in the human

Combination therapy (1,138 words) [view diff] exact match in snippet view article find links to article

(2014-01-30). "Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors". Cell Reports. 6 (2): 377–387. doi:10.1016/j.celrep.2013.12.035

Cell physiology (849 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

GSPT1 (1,153 words) [view diff] exact match in snippet view article find links to article

depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway". Molecular and Cellular Biology. 27 (16): 5619–29. doi:10.1128/MCB

HEAT repeat (3,022 words) [view diff] exact match in snippet view article find links to article

(2010). "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes". Genes Dev. 24 (18): 2019–2030. doi:10.1101/gad.1956410

Ibrilatazar (293 words) [view diff] exact match in snippet view article find links to article

the expression of the TRIB3 gene, leading to inhibition of the PI3K/AKT/mTOR pathway. This pathway is excessively activated in most human cancers, supporting

Restriction point (2,746 words) [view diff] exact match in snippet view article find links to article

degradation of cyclin D1 (see figure). Akt further regulates G1/S components by mTOR-mediated promotion of cyclin D1 translation, phosphorylation of the Cdk inhibitors

Carcinoid syndrome (1,823 words) [view diff] exact match in snippet view article find links to article

pasireotide may be effective. In patients who continue to be refractory, mTOR inhibitors such as everolimus. The TPH inhibitor telotristat ethyl may be

EIF3F (1,014 words) [view diff] exact match in snippet view article find links to article

Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO

Glutaminase (1,176 words) [view diff] exact match in snippet view article find links to article

glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling". Neurooncol Adv. 3 (1) vdaa149. doi:10.1093/noajnl/vdaa149. PMC 7920530

Tikona Infinet Limited (440 words) [view diff] exact match in snippet view article find links to article

synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition". PLOS One. 8 (8) e71138. Bibcode:2013PLoSO...871138C. doi:10

SHORT syndrome (489 words) [view diff] exact match in snippet view article find links to article

subunit of phosphatidylinositol 3-kinase. This mutation can alter the PI3K/AKT/mTOR signal route, which plays an important role in cell growth and proliferation

Euglenophycin (2,621 words) [view diff] exact match in snippet view article find links to article

anti-cancer potential. This may be caused by inhibiting the mTOR pathway because it is known that the mTOR pathway can have a significant effect on stimulating

ML-SI3 (394 words) [view diff] exact match in snippet view article find links to article

"Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR". PLOS Biology. 17 (5) e3000252. doi:10.1371/journal.pbio.3000252. PMC 6528971

PELP-1 (3,924 words) [view diff] exact match in snippet view article find links to article

extra-nuclear actions by coupling ESR1 with Src kinase PI3K STAT3 ILK1 and mTOR PELP1 participates in E2-mediated cell proliferation and is a substrate of

Buparlisib (690 words) [view diff] exact match in snippet view article find links to article

trial, the disease had to be resistant to a mammalian target of rapamycin (mTOR) inhibitor. The trial was terminated due to excessive side effects. The phase

Synaptic pruning (3,222 words) [view diff] exact match in snippet view article find links to article

during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity Faust, Travis

Diet-induced obesity model (4,758 words) [view diff] exact match in snippet view article find links to article

high-fat/high-density diets and obesity, including the discovery of Akt and mTOR, signals in the body linked to obesity and insulin resistance. However, while

Synaptic pruning (3,222 words) [view diff] exact match in snippet view article find links to article

during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity Faust, Travis

Amino acid neurotransmitter (200 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Metatorbernite (174 words) [view diff] case mismatch in snippet view article find links to article

General Category Phosphate minerals Formula Cu(UO2)2(PO4)2·8(H2O) IMA symbol Mtor Strunz classification 8.EB.10 Crystal system Tetragonal Crystal class Dipyramidal

ATL-444 (157 words) [view diff] exact match in snippet view article find links to article

Kim CS (May 2018). "Adenosine induces intrinsic apoptosis via the PI3K/Akt/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells". Oncology

Ovarian clear-cell carcinoma (968 words) [view diff] exact match in snippet view article find links to article

help their care. Some suggested therapeutic targets include the PI3K/AKT/mTOR, VEGF, Il-6/STAT3, MET, and HNF-1beta pathways. Better insight into genomic

Solobacterium moorei (1,463 words) [view diff] exact match in snippet view article find links to article

through its Cna B-type domain-containing protein. This activates the PI3K-AKT-mTOR-C-myc signaling pathway via phosphorylated Focal Adhesion Kinase (phospho-FAK)

Mir-199 microRNA precursor (1,301 words) [view diff] exact match in snippet view article find links to article

Croce CM, Bolondi L, Gramantieri L (June 2010). "MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma

Jordan's syndrome (782 words) [view diff] exact match in snippet view article find links to article

Studies of specific JS-causing variants such as E420K have implicated PI3K/AKT/mTOR pathway dysregulation in JS pathogenesis. Jordan's syndrome is diagnosed

EIF3A (1,367 words) [view diff] exact match in snippet view article find links to article

TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO

Tissue growth (673 words) [view diff] exact match in snippet view article find links to article

circulating hormones of the Insulin/IGF-1 family, which activate the PI3K/AKT/mTOR pathway in many cells of the body to increase the average rate of both cell

Β-Hydroxy β-methylbutyric acid (10,188 words) [view diff] exact match in snippet view article find links to article

skeletal muscle via phosphorylation of the mechanistic target of rapamycin (mTOR) and subsequent activation of mTORC1Tooltip mechanistic target of rapamycin

Pseudopodia (1,788 words) [view diff] exact match in snippet view article find links to article

plasma membrane generates protrusions via activation of the Ras-PI3K/AKT/mTOR signalling pathway. In the case there is no extracellular cue, all moving

Systemic inflammation (1,453 words) [view diff] exact match in snippet view article find links to article

2018.00754. ISSN 1664-3224. PMC 5908901. PMID 29706967. Green AS (2018). "mTOR, glycotoxins and the parallel universe". Aging. 10 (12): 3654–3656. doi:10

Neuroendocrine cell (928 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Second messenger system (1,364 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

AGPAT9 (569 words) [view diff] exact match in snippet view article find links to article

human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006

Transcription preinitiation complex (1,210 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Facial infiltrating lipomatosis (783 words) [view diff] exact match in snippet view article find links to article

drug treatment options are either a mTOR inhibitor, a pan AKT (AKT1-2-3) inhibitor or a PIK3CA inhibitor. The mTOR inhibitor is an off-label use, the use

Anne-Claude Gingras (1,013 words) [view diff] exact match in snippet view article find links to article

Anne-Claude (2001-04-01). "Regulation of translation initiation by FRAP/mTOR". Genes & Development. 15(7): 807–826. Sonenberg, Nahum; Aebersold, Ruedi;

Diffuse large B-cell lymphoma (8,171 words) [view diff] exact match in snippet view article find links to article

neoplastic cells in DLBCL, NOS exhibit pathologically overactive NF-κB, PI3K/AKT/mTOR, JAK-STAT0, MAPK/ERK, B-cell receptor, toll-like receptor, and NF-κB signaling

KLF15 (2,816 words) [view diff] exact match in snippet view article find links to article

genes of the glucocorticoid receptor (GR) in skeletal muscle. KLF15 inhibits mTOR activity via a distinct mechanism involving BCAT2 gene activation. KLF15

Anne-Claude Gingras (1,013 words) [view diff] exact match in snippet view article find links to article

Anne-Claude (2001-04-01). "Regulation of translation initiation by FRAP/mTOR". Genes & Development. 15(7): 807–826. Sonenberg, Nahum; Aebersold, Ruedi;

DDX21 (986 words) [view diff] exact match in snippet view article find links to article

C-jun. DDX21 has been reported to bind to AU-rich elements (AREs) and confer mTOR-mediated translation control during T cell activation. GRCh38: Ensembl release

Menerba (1,115 words) [view diff] exact match in snippet view article find links to article

"Timosaponin AIII is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress". PLOS ONE. 4 (9) e7283. Bibcode:2009PLoSO...4

Zinc transporter SLC39A7 (1,968 words) [view diff] exact match in snippet view article find links to article

negatively regulates ZIP7, inhibiting ZIP7-mediated activation of the Akt/mTOR pathway, thereby suppressing cell proliferation and migration while promoting

Ribavirin (4,755 words) [view diff] exact match in snippet view article find links to article

et al. (2015-08-28). Eaves CJ (ed.). "Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase

Indatraline (622 words) [view diff] exact match in snippet view article find links to article

indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway". Scientific Reports. 6 (1) 34655. Bibcode:2016NatSR

Rapt (184 words) [view diff] exact match in snippet view article find links to article

the float plane industry being developed by Tigerfish Aviation RAPT1 or mTOR, the mammalian target of rapamycin protein RATP Group (Régie Autonome des

Joan Brugge (1,484 words) [view diff] exact match in snippet view article find links to article

L Song, FC Morales, S Gao, GB Mills and JS Brugge. "Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells." Cancer Cell

COASY (1,018 words) [view diff] exact match in snippet view article find links to article

interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Letters. 578 (3):

Autocrine signaling (2,105 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

FKBP1A (1,826 words) [view diff] exact match in snippet view article find links to article

muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science. 118 (Pt 23): 5443–51. doi:10.1242/jcs

Right ventricular hypertrophy (1,696 words) [view diff] exact match in snippet view article find links to article

only cause of RVH. Hypertrophy can also be caused by mechanical forces, mTOR pathways, nitric oxide and immune cells. Immune cells can cause hypertrophy

Interleukin 2 (5,021 words) [view diff] exact match in snippet view article find links to article

signaling pathways; they are: (1) the JAK-STAT pathway, (2) the PI3K/Akt/mTOR pathway and (3) the MAPK/ERK pathway. The signalling is commenced by IL-2

Eganelisib (803 words) [view diff] exact match in snippet view article find links to article

and thus works by inhibiting the enzyme PIK3CG, disrupting the PI3K/AKT/mTOR signaling pathway which plays important roles in the development of cancer

Neuropeptide (2,922 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Uterine cancer (2,085 words) [view diff] exact match in snippet view article find links to article

endometrial cancer. Targeted therapy may include monoclonal antibodies, mTOR inhibitors, and signal transduction inhibitors which all act to target cancer

Ghrelin (4,838 words) [view diff] exact match in snippet view article find links to article

communication pathways are probable, including the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid

Endocrine therapy resistance in breast cancer (3,317 words) [view diff] exact match in snippet view article find links to article

downregulated when there is activation of growth factors via the PI3K/Akt/mTOR pathway. Over-expression of HER2 is found to be present in around 30% of

Apurva Sarin (605 words) [view diff] exact match in snippet view article find links to article

hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells". Cell

Type I topoisomerase (2,348 words) [view diff] exact match in snippet view article find links to article

PMID 23377825. Dominick G, Bowman J, Li X, Miller RA, Garcia GG (2016). "mTOR regulates the expression of DNA damage response enzymes in long-lived Snell

Johns Hopkins School of Medicine (2,618 words) [view diff] exact match in snippet view article find links to article

former Howard Hughes Investigator and molecular biologist who discovered mTOR, the mammalian target of rapamycin Florence Sabin, first woman to hold a

ARIAD Pharmaceuticals (1,397 words) [view diff] exact match in snippet view article find links to article

Brigatinib was designated a Breakthrough Medicine by the FDA. Ridaforolimus is an mTOR inhibitor being developed by Medinol Ltd for use in drug-eluting stents for

Auranofin (1,527 words) [view diff] exact match in snippet view article find links to article

1126/scitranslmed.abq5931. PMC 11457891. PMID 36383684. S2CID 253554150. "PKCι & mTOR Inhibition With Auranofin+Sirolimus for Squamous Cell Lung Cancer". Retrieved

SLAMF1 (2,009 words) [view diff] exact match in snippet view article find links to article

cases). It regulates cancer cell growth and survival by activating PI3K/Akt/mTOR signaling pathway. Therefore, SLAMF1 could be used as a diagnostical and

Duvelisib (1,322 words) [view diff] exact match in snippet view article find links to article

repair, senescence, angiogenesis and cell metabolism, including the PI3K/AKT/mTOR pathway. Duvelisib, also known as IPI-145, was discovered by Intellikine

Oncolytic AAV (1,345 words) [view diff] exact match in snippet view article find links to article

also been investigated in combination with AAV-2-mTOR which targets the mammalian target of rapamycin (mTOR), an investigated anti-cancer target. AAV-DC-CTL:

NAS Award in Molecular Biology (1,796 words) [view diff] exact match in snippet view article find links to article

David M. Sabatini for his discovery of components and regulators of the mTOR kinase pathway and his elucidation of the important roles of this signaling

Juxtacrine signalling (1,361 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Cartilage (3,944 words) [view diff] exact match in snippet view article find links to article

Tariq M. (2018-09-05). "Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes"

Companies listed on the New York Stock Exchange (M) (28 words) [view diff] exact match in snippet view article

Meredith Corporation MDP US Meritage Homes Corporation MTH US Meritor, Inc. MTOR US Merrill Lynch Capital Trust I MER.PRK US Merrill Lynch Capital Trust II

Owen McCarty (1,024 words) [view diff] exact match in snippet view article find links to article

11(1), 35-46. Itakura, A., & McCarty, O. J. (2013). Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation

Duojia Pan (910 words) [view diff] exact match in snippet view article find links to article

these tumor suppressor genes to Rheb and mTOR signaling. This discovery provided the molecular basis for using mTOR inhibitors in the treatment of tuberous

Apoptosis-inducing factor (1,127 words) [view diff] exact match in snippet view article find links to article

RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones

Tivozanib (1,189 words) [view diff] exact match in snippet view article find links to article

adults with advanced renal cell carcinoma and for adults who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment

Cardiac allograft vasculopathy (1,959 words) [view diff] exact match in snippet view article find links to article

after heart transplantation too. On detection of CAV, medications including mTOR inhibitors sirolimus and everolimus have been shown to slow disease progression