Find link

language:

Find link is a tool written by Edward Betts.

searching for EZH2 53 found (100 total)

alternate case: eZH2

FAS-AS1 (357 words) [view diff] exact match in snippet view article find links to article

skipping. EZH2, often mutated or overexpressed in lymphomas, hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated

Mevrometostat (1,037 words) [view diff] exact match in snippet view article find links to article

functions as a potent and selective inhibitor of enhancer of zeste homolog 2 (EZH2). Currently under development by Pfizer, mevrometostat is being investigated

SUZ12 (1,230 words) [view diff] exact match in snippet view article find links to article

histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Molecular Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020

Synthetic lethality (2,839 words) [view diff] exact match in snippet view article find links to article

expression occurs by either inhibition of the methyltransferase activity of EZH2, by inhibition of the DNA repair kinase ATR, or by exposure to the kinase

Mir-124 microRNA precursor family (645 words) [view diff] case mismatch in snippet view article find links to article

the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression". The Journal of Biological Chemistry. 289 (30): 20788–20801.

Epigenetics of chronic pain (2,210 words) [view diff] exact match in snippet view article find links to article

mediated by the PCR2 complex. PCR2 has a methyltransferase EZH2. Nerve damage stimulates EZH2 expression and increases the enrichment of H3K27me3 at the

PPP1R8 (1,231 words) [view diff] exact match in snippet view article find links to article

shown to interact with PPP1CA, Histone deacetylase 2, SF3B1 EED and the EZH2 domain of PRC2. GRCh38: Ensembl release 89: ENSG00000117751 – Ensembl, May

Mesenchymal stem cell (5,463 words) [view diff] exact match in snippet view article find links to article

their multipotency. Recent work suggests that β-catenin, via regulation of EZH2, is a central molecule in maintaining the "stemness" of MSCs. The standard

UHRF1 (3,306 words) [view diff] exact match in snippet view article find links to article

reduces H3K27 methylation and limits the oncogenic properties of EZH2 by phosphorylating EZH2-T311. Experiments in mouse models have indicated that UHRF1 can

Mammalian SWI/SNF (BAF) complex (10,609 words) [view diff] exact match in snippet view article

epithelioid sarcoma, causes early dependence on EZH2 activity. Similarly, inhibition of EZH2 by the EZH2 inhibitor tazemetostat has shown clinical activity

NKX3-1 (2,371 words) [view diff] exact match in snippet view article find links to article

NKX3-1 was controlled by ERG and ESE3 both directly and through induction of EZH2 (Polycomb group pcg). Using a random cDNA sequencing approach, He et al.

Oncogenomics (7,688 words) [view diff] exact match in snippet view article find links to article

deficiency occurs by either inhibition of the methyltransferase activity of EZH2, or with addition of the kinase inhibitor dasatinib. Another approach is

Genentech (2,907 words) [view diff] exact match in snippet view article find links to article

partnered Epizyme to conduct clinical trials exploring whether Epizyme's EZH2 inhibitor tazemetostat would be synergistic with Genentech's atezolizumab

BCL6 (2,449 words) [view diff] exact match in snippet view article find links to article

BCL6’s interaction with other mutated proteins, including CREBBP, EP300, EZH2, and KM2TD, can also lead to B-cell lymphomas. Given its role as a master

Hovlinc (344 words) [view diff] exact match in snippet view article find links to article

retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2". Proceedings of the National Academy of Sciences. 117 (1): 415–425. Bibcode:2020PNAS

Daiichi Sankyo (2,402 words) [view diff] exact match in snippet view article find links to article

Enhertu". PMLive. 23 December 2019. Retrieved 3 December 2020. "Dual EZH1 and EZH2 inhibitor Ezharmia launched in Japan". The Pharma Letter. 20 December 2022

Mir-205 (2,700 words) [view diff] exact match in snippet view article find links to article

to be involved in disease progression (i.e., interleukin 6, caveolin-1, EZH2). It also impaired cell growth, migration, clonability, and invasiveness

Cancer epigenetics (12,571 words) [view diff] exact match in snippet view article find links to article

chondrosarcoma, Ewing's sarcoma, and osteosarcoma, and expression of the EZH2 component of the PRC2 complex is altered in Ewing's sarcoma and rhabdomyosarcoma

Multiple myeloma (13,284 words) [view diff] exact match in snippet view article find links to article

polycomb repressive complex 2 (PRC2). Increased expression of the PRC2 subunit, EZH2 have been described to be a common feature in multiple myeloma, resulting

Carla F. Kim (758 words) [view diff] exact match in snippet view article find links to article

Yi-Jang; Zhang, Haikuo; Marquez, Victor E.; Hammerman, Peter S. (2015-04-09). "EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors"

Human cytomegalovirus (6,503 words) [view diff] exact match in snippet view article find links to article

Racha; Bibeau, Frédéric; Herbein, Georges (October 2023). "Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian

Jessamy Tiffen (813 words) [view diff] exact match in snippet view article find links to article

prostate cancer progression". scholar.google.com.au. Retrieved 7 October 2023. "EZH2 inhibitors in immunotherapy of melanoma". scholar.google.com.au. Retrieved

RNA immunoprecipitation chip (1,434 words) [view diff] case mismatch in snippet view article find links to article

immunoprecipitation procedure with RNA sequencing. Using specific antibodies (α-Ezh2) they immunoprecipitated nuclear RNA isolated from mouse ES cells, and subsequently

HOTAIR (1,241 words) [view diff] case mismatch in snippet view article find links to article

Neubert TA, Reinberg D (December 2010). "Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA". Genes & Development

Weiping Zou (877 words) [view diff] exact match in snippet view article find links to article

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nature immunology, doi:10.1038/ni.3313 (2016)

Cytoskeleton regulator RNA (583 words) [view diff] exact match in snippet view article find links to article

non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer". Oncotarget. 7 (9): 9773–87

EHF (gene) (873 words) [view diff] exact match in snippet view article

C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate

EPC1 (645 words) [view diff] exact match in snippet view article find links to article

complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10

MDL-811 (213 words) [view diff] exact match in snippet view article find links to article

SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis". Acta Pharmaceutica Sinica. B. 11 (3): 708–726. doi:10.1016/j

Enhancer of polycomb homolog 2 (drosophila) (516 words) [view diff] exact match in snippet view article

E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology

Jeannie T. Lee (1,441 words) [view diff] exact match in snippet view article find links to article

Alfredo J.; Lee, Jeannie T. (2016-12-15). "Destabilization of B2 RNA by EZH2 Activates the Stress Response". Cell. 167 (7): 1788–1802.e13. doi:10.1016/j

Glioblastoma (9,286 words) [view diff] exact match in snippet view article find links to article

Pasquereau S, Haidar Ahmad S, Monnien F, Abad M, Bibeau F, et al. (9 June 2023). "EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes"

Structural Genomics Consortium (5,329 words) [view diff] exact match in snippet view article find links to article

include PFI-1 and JQ1 for the BET family, UNC0642 for G9a/GLP, UNC1999 for EZH2/H1, LLY-283 and GSK591 for PRMT5, and OICR-9429 for WDR5. The WDR5 chemical

Azithromycin (5,756 words) [view diff] exact match in snippet view article find links to article

inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2". Clin Epigenetics. 15 (1) 12. doi:10.1186/s13148-023-01430-y. PMC 9872437

DAB2IP (861 words) [view diff] case mismatch in snippet view article find links to article

(2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer". J. Biol. Chem. 280 (23):

Alpha-methylacyl-CoA racemase (2,234 words) [view diff] exact match in snippet view article find links to article

Otte AP, Rubin MA, Chinnaiyan AM (Oct 2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer" (PDF). Nature. 419 (6907):

Baek Sung-hee (1,092 words) [view diff] exact match in snippet view article find links to article

Noh, Dong-Young; Kim, Keun Il; Kim, Kyeong Kyu; Baek, Sung Hee (2012). "EZH2 Generates a Methyl Degron that is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin

YWHAZ (3,622 words) [view diff] exact match in snippet view article find links to article

C, Ding J, Liao G, Tang B (2014). "Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular

Douglas Scherr (2,304 words) [view diff] exact match in snippet view article find links to article

DS; Gudas, LJ (2005). "Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder". Clinical Cancer Research

Ankur Singh (2,678 words) [view diff] exact match in snippet view article find links to article

Matt F.; Elemento, Olivier; Singh, Ankur; Melnick, Ari M. (2017-10-12). "EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A

ARMH1 (1,743 words) [view diff] exact match in snippet view article find links to article

cycle regulators, including CDCA7 and EZH2. The research also uncovered that ARMH1 physically interacts with EZH2, a protein implicated in multiple cancers

RNF144A (911 words) [view diff] exact match in snippet view article find links to article

(November 2017). "Targeting glioma stem cells through combined BMI1 and EZH2 inhibition". Nature Medicine. 23 (11): 1352–1361. doi:10.1038/nm.4415. PMC 5679732

Intravascular lymphomas (4,735 words) [view diff] exact match in snippet view article find links to article

Hacioglu S, Sari I, Bagci G, Keskin A (March 2016). "Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B

Extranodal NK/T-cell lymphoma, nasal type (5,489 words) [view diff] exact match in snippet view article find links to article

thereby rendering them resistant to this class of chemotherapy drugs; 4) EZH2, a histone methyltransferase that when up-regulated indirectly promotes these

Ataxia–telangiectasia (10,879 words) [view diff] exact match in snippet view article find links to article

Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K (December 2013). "EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia–telangiectasia"

Pharmacoepigenetics (4,224 words) [view diff] exact match in snippet view article find links to article

lead to another type of cancer. Trying to modify these proteins, such as EZH2, may give rise to other types of cancer. Selectivity is another hurdle in

Mir-25 microRNA precursor family (2,367 words) [view diff] exact match in snippet view article find links to article

development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2". The Journal of Clinical Endocrinology and Metabolism. 97 (5): E710-8. doi:10

Robert E. Kingston (2,269 words) [view diff] case mismatch in snippet view article find links to article

the formation of diseases, Kingston's discovery of direct interactions (Ezh2 subunit) and PRC2 cofactors (Gtl2 RNA) contributed to identifying the function

Farah Lubin (2,466 words) [view diff] exact match in snippet view article find links to article

1038/s41598-018-37761-7 Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD. 2018. EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During

AEBP2 (327 words) [view diff] exact match in snippet view article find links to article

histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548

Genome-wide CRISPR-Cas9 knockout screens (6,176 words) [view diff] exact match in snippet view article find links to article

"CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2". The Journal of Clinical Investigation. 128 (1): 446–462. doi:10.1172/JCI90793

Steven A. Johnsen (3,112 words) [view diff] exact match in snippet view article find links to article

Sebastian; Brunner, Marius; Gaedcke, Jochen; Ströbel, Philipp (2020-11-01). "EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional

Pure apocrine carcinoma of the breast (5,092 words) [view diff] exact match in snippet view article find links to article

Lytle A, Chiriboga L, Ozerdem U (September 2020). "The diagnostic utility of EZH2 H-score and Ki-67 index in non-invasive breast apocrine lesions". Pathology